SBS Signatures
DBS Signatures
ID Signatures
CN Signatures
SV Signatures
RNA SBS Signatures
Version 2 Signatures
SigProfiler Tools

Mutational Signatures (v3.4 - October 2023)

RNA Single Base Substitution (RNA-SBS) Signatures

RNA Single Base Substitution (RNA SBS) signatures are defined using the 192-channel for the tri-nucleotide context of every possible point nucleotide change on an RNA molecule. Because RNA molecules are single-stranded, we can infer the exact nucleotide change, thus resulting in the 192 channel, unlike DNA single base substitutions, where the strandedness of the nucleotide change cannot always be inferred. The signatures displayed here were identified from 333 non-small cell lung cancer tumours from the TRACERx (TRAcking Cancer Evolution through therapy (Rx)) cohort.