This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Hypoxia inducible factor pathway
- Study ID
- This gene set includes proteins which are involved in the hypoxia inducible factor (HIF) pathway. Under normoxic conditions, HIF1a is inactive but on exposure to prolonged hypoxia, transcriptional coactivators such as CREBBP and EP300 bind HIF1a activating it. Activated HIF1a binds to the hypoxia response element of target gene promoters. This activates transcription of over 40 genes whose products increase oxygen delivery or allow cellular adaptation to hypoxia. This pathway plays an essential role in tumour angiogenesis, embryonic vascularisation and the pathophysiology of ischemic disease.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples