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Cosmic » Study » Overview » Renal: Growth Arrest Specific Genes.View in GRCh37 Archive

This tab shows an overview of the selected study/paper [more details]
Study
Renal: Growth Arrest Specific Genes.
Study Id
COSU186
Description
Growth arrest specific (GAS) genes were initially identified due to their high expression in 3T3 fibroblasts following growth arrest. The products of these genes can negatively or positively regulate cell proliferation, differentiation and apoptosis. GAS1 has been shown to block the cell cycle at the point of entry into S phase while GAS2 is implicated in morphological changes in the cell leading to apoptosis. Deletions spanning the chromosomal region containing the GAS1 gene have been associated with several types of cancer.

Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
Genes Analysed
6
Mutated Samples
0
Total No. of Samples
96
This tab shows the correlation plot between top 20 genes and samples [more details]

This tab shows genes with mutations in the selected study/paper [more details]
Genes Samples CDS Mutation AA Mutation
This tab shows non coding variant in the selected study/paper [more details]
Sample ID Sample Name ID NCV Annotation Zygosity Chromosome Genome start Genome stop Genome version Strand WT seq Mut seq FATHMM-MKL
This tab shows the gene expression and copy number variation data for this study. [more details]

Table Information

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The table currently shows only high value (numeric) copy number data. Copy number segments are excluded if the total copy number and minor allele values are unknown.

Click here to include all copy number data. For more detailed information about copy number data and gain/loss definitions click here.

Sample Gene Expression Expr Level (Z-Score)

Over Expressed; Z-Score > 2.0

Under Expressed; Z-Score < -2.0

Normal; Z-Score within the range -2.0 to 2.0

 CN Type Minor Allele Copy Number CN Segment Posn. Average Ploidy

1. N/A represents cases where the average ploidy value is not available( mostly ICGC samples). For some TCGA samples where the minor allele information is not available the average ploidy value could not be calculated.

2. For TCGA samples, the ASCAT algorithm was used to calculate the average ploidy.

3. For CGP samples, the PICNIC algorithm was used to calculate the average ploidy.

 CNV
This table lists the samples in the selected study which have low/high methylation for each gene. [more details]
  Methylation (no. samples)
Tissue Gene Probe Position Low High Tested
This tab shows the fusion mutations observed in this sample [more details]
Gene Sample Name Id Sample(COSS) CDS Mutation Somatic status Zygosity Validated Type

This tab shows genes with mutations in the selected study/paper [more details]
Genes Mutated Samples
This tab shows genes without mutations in the selected study/paper [more details]
Non-Mutant Genes Gene Id (COSG)

This tab shows samples without mutations in the selected study/paper [more details]
Non-Mutant Samples Sample Id (COSS)
This tab shows mutated samples in the selected study/paper [more details]
Sample Name Mutation Count