This section shows a general overview of information for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the WTSI Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Renal: Forkhead transcription factor family
- Study ID
- Forkhead box proteins (FOX proteins) are so called because they share a forkhead or "winged helix" domain. The forkhead domain binds B-DNA as a monomer but has a structure unlike other DNA binding motifs. The domain is found in many different transcription factors which all seem to have a role in early developmental cell fate decisions during embryogenesis. The FOX proteins play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Some FOX genes are downstream targets of the hedgehog signalling pathway, which plays a role in the development of basal cell. Forkhead genes have been found in translocations in acute leukemia and alveolar rhabdomyosarcoma.
Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.
- Genes Analysed
- Mutated Samples
- Total No. of Samples