Renal: Forkhead transcription factor family

COSU183

Forkhead box proteins (FOX proteins) are so called because they share a forkhead or "winged helix" domain. The forkhead domain binds B-DNA as a monomer but has a structure unlike other DNA binding motifs. The domain is found in many different transcription factors which all seem to have a role in early developmental cell fate decisions during embryogenesis. The FOX proteins play important roles in regulating the expression of genes involved in cell growth, proliferation, differentiation, and longevity. Some FOX genes are downstream targets of the hedgehog signalling pathway, which plays a role in the development of basal cell. Forkhead genes have been found in translocations in acute leukemia and alveolar rhabdomyosarcoma.

Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.

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