COSMIC: Study Overview

Cosmic » Study » Overview » Renal: Heat shock proteinsView in GRCh37 Archive

Overview
Mutation Matrix
Genes
Variants
Samples

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StudyRenal: Heat shock proteinsStudy IdCOSU177DescriptionHeat shock protein proteins (HSPs) are so called because of the up regulation in their  expression when cells are exposed to stress like heat, cold, toxins and hypoxia. In  addition to their role in the stress response, HSPs also act as chaperones mediating  normal protein folding, trafficking and degradation. HSPs have also been associated with  functions as diverse as initiation of translation, controlling apoptosis and mediating the  immune response. This group of genes code for many HSPs including DNAJ (HSP40) homologues  and other associated proteins. HSP genes are involved in translocations in NHL.

Sequencing of any given sample through the gene sets should be considered work in progress. Lack of reported mutations in any given gene for a particular sample does not necessarily imply the sample is wildtype for the gene.Genes Analysed42Mutated Samples4Total No. of Samples96

Coding Mutations
Non-Coding Mutations
CNV & Expr
Methylation
Fusions

Genes	Samples	CDS Mutation	AA Mutation

Sample ID	Sample Name	ID NCV	Annotation	Zygosity	Chromosome	Genome start	Genome stop	Genome version	Strand	WT seq	Mut seq	FATHMM-MKL

Table Information

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The table currently shows only high value (numeric) copy number data. Copy number segments are excluded if the total copy number and minor allele values are unknown.

Click here to include all copy number data. For more detailed information about copy number data and gain/loss definitions click here.

Sample	Gene	Expression	Expr Level (Z-Score) Over Expressed; Z-Score > 2.0 Under Expressed; Z-Score < -2.0 Normal; Z-Score within the range -2.0 to 2.0	CN Type	Minor Allele	Copy Number	CN Segment Posn.	Average Ploidy 1. N/A represents cases where the average ploidy value is not available( mostly ICGC samples). For some TCGA samples where the minor allele information is not available the average ploidy value could not be calculated. 2. For TCGA samples, the ASCAT algorithm was used to calculate the average ploidy. 3. For CGP samples, the PICNIC algorithm was used to calculate the average ploidy.	CNV

				Methylation (no. samples)
Tissue	Gene	Probe	Position	Low	High	Tested

Gene	Sample Name	Id Sample(COSS)	CDS Mutation	Somatic status	Zygosity	Validated	Type

Mutant Genes
Non-Mutant Genes

Genes	Mutated Samples

Non-Mutant Genes	Gene Id (COSG)

Mutant Samples
Non-Mutant Samples

Non-Mutant Samples	Sample Id (COSS)

Sample Name	Mutation Count