Reference Overview - PMID19330029

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Reference

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Paper Id
COSP21452
Authors
van Haaften G,Dalgliesh GL,Davies H,Chen L,Bignell G,Greenman C,Edkins S,Hardy C,O'Meara S,Teague J,Butler A,Hinton J,Latimer C,Andrews J,Barthorpe S,Beare D,Buck G,Campbell PJ,Cole J,Forbes S,Jia M,Jones D,Kok CY,Leroy C,Lin ML,McBride DJ,Maddison M,Maquire S,McLay K,Menzies A,Mironenko T,Mulderrig L,Mudie L,Pleasance E,Shepherd R,Smith R,Stebbings L,Stephens P,Tang G,Tarpey PS,Turner R,Turrell K,Varian J,West S,Widaa S,Wray P,Collins VP,Ichimura K,Law S,Wong J,Yuen ST,Leung SY,Tonon G,DePinho RA,Tai YT,Anderson KC,Kahnoski RJ,Massie A,Khoo SK,Teh BT,Stratton MR and Futreal PA
Affiliation
Wellcome Trust Sanger Institute, Hinxton, UK.
Journal
Nature genetics 2009;41(5):521-3
ISSN:1546-1718
PUBMED:19330029
Abstract
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
Paper Status
Curated
Genes Analysed
1
Mutations
44

Mutations

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Genes Samples CDS Mutation AA Mutation

Non-Mutant Genes

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Non-Mutant Genes Gene Id (COSG)

Non-Mutant Samples

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Non-Mutant Samples Sample Id (COSS)

Mutated Samples

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Sample Name Mutation Count

Non-Coding mutation

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Sample ID Sample Name ID NCV Annotation Zygosity Chromosome Genome start Genome stop Genome version Strand WT seq Mut seq