Mutation Overview - IL1B - p.E111K(Substitution - Missense)

Cosmic » Mutation » Overview » IL1B » p.E111K / c.331G>A

Overview

This tab shows an overview of the mutation data [more details]
  • Description:
  • Mutation id:
  • AA Mutation:
  • CDS Mutation:
  • GRCH 37:
  • Cancer Genome Browser:
  • CDD:
  • Homologene:
  • Ever confirmed somatic:

Tissue Distribution

This tab displays the distribution of mutated samples and tissue types. [more details]

Samples

This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene Name Transcript Primary Tissue Histology Pubmed Id Zygosity Somatic Status

Protein features

This tab displays a table of protein features [more details]
View Identifier Source Feature Start End Status Score
P01584 PTHR10078:SF20 PTHR10078:SF20 24 268 Overlap 100.00
IL1B MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG 60 P01584 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG 60 IL1B FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR 120 P01584 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR 120 IL1B SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE 180 P01584 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE 180 IL1B KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST 240 P01584 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST 240 IL1B SQAENMPVFLGGTKGGQDITDFTMQFVSS P01584 SQAENMPVFLGGTKGGQDITDFTMQFVSS

More details

Wildtype Residue : E Mutant Position : 111 Mutant label : p.E111K Feature Name :PTHR10078:SF20( 24- 268 )
P01584 PTHR10078 PTHR10078 24 268 Overlap 100.00
IL1B MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG 60 P01584 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG 60 IL1B FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR 120 P01584 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR 120 IL1B SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE 180 P01584 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE 180 IL1B KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST 240 P01584 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST 240 IL1B SQAENMPVFLGGTKGGQDITDFTMQFVSS P01584 SQAENMPVFLGGTKGGQDITDFTMQFVSS

More details

Wildtype Residue : E Mutant Position : 111 Mutant label : p.E111K Feature Name :PTHR10078( 24- 268 )
P01584 UniProt:curator UNIPROTKB_P01584_PROPEP_1_116 1 116 Overlap 100.00
IL1B MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG 60 P01584 MAEVPELASEMMAYYSGNEDDLFFEADGPKQMKCSFQDLDLCPLDGGIQLRISDHHYSKG 60 IL1B FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR 120 P01584 FRQAASVVVAMDKLRKMLVPCPQTFQENDLSTFFPFIFEEEPIFFDTWDNEAYVHDAPVR 120 IL1B SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE 180 P01584 SLNCTLRDSQQKSLVMSGPYELKALHLQGQDMEQQVVFSMSFVQGEESNDKIPVALGLKE 180 IL1B KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST 240 P01584 KNLYLSCVLKDDKPTLQLESVDPKNYPKKKMEKRFVFNKIEINNKLEFESAQFPNWYIST 240 IL1B SQAENMPVFLGGTKGGQDITDFTMQFVSS P01584 SQAENMPVFLGGTKGGQDITDFTMQFVSS

More details

Wildtype Residue : E Mutant Position : 111 Mutant label : p.E111K Feature Name :UNIPROTKB_P01584_PROPEP_1_116( 1- 116 )

Pathways Affected

This tab displays a table of pathways affected by the mutation [more details]
Source Pathways
Reactome Signaling in Immune system
WikiPathway NOD pathway
WikiPathway Regulation of toll-like receptor signaling pathway
WikiPathway Selenium
WikiPathway SERT
WikiPathway Vitamin B12
WikiPathway Folate
WikiPathway IL-1 Signaling Pathway
WikiPathway Myometrial Relaxation and Contraction Pathways
WikiPathway MAPK signaling pathway
WikiPathway Cytokines and Inflammatory Response (BioCarta)
WikiPathway Type II interferon signaling (IFNG)
WikiPathway Senescence and Autophagy
WikiPathway VandyConte::Blakely Network
WikiPathway Toll-like receptor signaling pathway

References

This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed