This tab shows an overview of the mutation data [more details]
Gene Name:
Mutation Id:
AA Mutation:
p.E545K (Substitution - Missense, position 545, EK)
CDS Mutation:
c.1633G>A (Substitution, position 1633, GA)
3:179218303..179218303, view Ensembl Contig
COSMIC Genome Browser:
3:179218303..179218303, view in COSMIC JBrowse
21249, view the multiple sequence alignment.
Ever confirmed somatic:
FATHMM prediction:
Pathogenic (score 0.97)
Observed conferring resistance to:
In the samples curated with this mutation, resistance has been observed for the drugs listed. However, the same resistance pattern may not apply to all samples. For more details, please look at the Samples tab.
This tab displays the distribution of mutated samples and tissue types. [more details]
This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene name Transcript Primary Tissue Histology Pubmed ID Zygosity Somatic Status Sample Source LOH Resistant Mutation Drugs
This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed