Mutation Overview - HS3ST3A1 - p.T236P(Substitution - Missense)

Cosmic » Mutation » Overview » HS3ST3A1 » p.T236P / c.706A>C

Overview

This tab shows an overview of the mutation data [more details]
  • Description:
  • Mutation id:
  • AA Mutation:
  • CDS Mutation:
  • NCBI 36:
  • GRCH 37:
  • Cancer Genome Browser:
  • CDD:
  • Homologene:
  • Ever confirmed somatic:

Tissue Distribution

This tab displays the distribution of mutated samples and tissue types. [more details]

Samples

This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene Name Transcript Primary Tissue Histology Pubmed Id Zygosity Somatic Status

Protein features

This tab displays a table of protein features [more details]
View Identifier Source Feature Start End Status Score
PF00685 Pfam Sulfotransfer_1:152-399 152 399 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :Sulfotransfer_1:152-399( 152- 399 )
Q9Y663 G3DSA:3.40.50.300 G3DSA:3.40.50.300 146 405 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :G3DSA:3.40.50.300( 146- 405 )
Q9Y663 Sulfotransfer_1 Sulfotransfer_1 153 388 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :Sulfotransfer_1( 153- 388 )
Q9Y663 PTHR10605:SF8 PTHR10605:SF8 13 406 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :PTHR10605:SF8( 13- 406 )
Q9Y663 PTHR10605 PTHR10605 13 406 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :PTHR10605( 13- 406 )
Q9Y663 SSF52540 SSF52540 136 406 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :SSF52540( 136- 406 )
Q9Y663 UniProt:curator Heparan sulfate glucosamine 3-O- sulfotransferase 3A1 1 406 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :Heparan sulfate glucosamine 3-O- sulfotransferase 3A1( 1- 406 )
Q9Y663 UniProt:curator Lumenal 44 406 Overlap 100.00
HS3ST3A1 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 Q9Y663 MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGG 60 HS3ST3A1 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 Q9Y663 EEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGL 120 HS3ST3A1 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 Q9Y663 SGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRA 180 HS3ST3A1 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 Q9Y663 VGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIV 240 HS3ST3A1 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 Q9Y663 VVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLR 300 HS3ST3A1 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 Q9Y663 HFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSR 360 HS3ST3A1 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG Q9Y663 PHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG

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Wildtype Residue : T Mutant Position : 236 Mutant label : p.T236P Feature Name :Lumenal( 44- 406 )

Pathways Affected

This tab displays a table of pathways affected by the mutation [more details]
Source Pathways
Reactome
WikiPathway metapathway biotransformation

References

This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed