Cosmic » Mutation » Overview » ATF1 » p.R228G / c.682C>G
Overview
This tab shows an overview of the mutation data [more details]
- Description:
- Mutation id:
- AA Mutation:
- CDS Mutation:
- NCBI 36:
- GRCH 37:
- Cancer Genome Browser:
- CDD:
- Homologene:
- Ever confirmed somatic:
- ATF1
- COSM69742
- p.R228G ( Substitution - Missense )
- c.682C>G ( Substitution )
- Ensembl Contig View: 12: 49499695..49499695
- Ensembl Contig View: 12: 51213428..51213428
- COSMIC GBrowse: 12: 51213428..51213428
- NP_005162.1
- 3790 , click here to look the multiple sequence alignment.
- Yes
Tissue Distribution
This tab displays the distribution of mutated samples and tissue types.
[more details]
Samples
This tab displays a table of muated samples, with tissue, histology and zygosity information.
Publication information is also included, where available, with links to PUBMED.
[more details]
| Sample name | Gene Name | Transcript | Primary Tissue | Histology | Pubmed Id | Zygosity | Somatic Status |
|---|
Protein features
This tab displays a table of protein features
[more details]
| View | Identifier | Source | Feature | Start | End | Status | Score |
|---|---|---|---|---|---|---|---|
| P18846 | G3DSA:1.20.5.170 | G3DSA:1.20.5.170 | 215 | 269 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :G3DSA:1.20.5.170( 215- 269 ) | |||||||
| P18846 | bZIP_1 | bZIP_1 | 212 | 268 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :bZIP_1( 212- 268 ) | |||||||
| P18846 | BZIP_BASIC | BZIP_BASIC | 219 | 233 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :BZIP_BASIC( 219- 233 ) | |||||||
| P18846 | BZIP | BZIP | 213 | 264 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :BZIP( 213- 264 ) | |||||||
| P18846 | PTHR22952:SF16 | PTHR22952:SF16 | 9 | 271 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :PTHR22952:SF16( 9- 271 ) | |||||||
| P18846 | PTHR22952 | PTHR22952 | 9 | 271 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :PTHR22952( 9- 271 ) | |||||||
| P18846 | BRLZ | BRLZ | 211 | 268 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :BRLZ( 211- 268 ) | |||||||
| P18846 | UniProt:curator | Cyclic AMP-dependent transcription factor ATF-1 | 1 | 271 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :Cyclic AMP-dependent transcription factor ATF-1( 1- 271 ) | |||||||
| P18846 | UniProt:curator | bZIP | 213 | 271 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :bZIP( 213- 271 ) | |||||||
| P18846 | UniProt:curator | Basic motif | 215 | 239 | Overlap | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :Basic motif( 215- 239 ) | |||||||
| P18846 | UniProt:curator | UNIPROTKB_P18846_CONFLICT_227_227 | 227 | 227 | Proximity | 100.00 | |
|
ATF1 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
P18846 MEDSHKSTTSETAPQPGSAVQGAHISHIAQQVSSLSESEESQDSSDSIGSSQKAHGILAR 60
ATF1 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
P18846 RPSYRKILKDLSSEDTRGRKGDGENSGVSAAVTSMSVPTPIYQTSSGQYIAIAPNGALQL 120
ATF1 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
P18846 ASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQ 180
ATF1 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
P18846 IRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKC 240
ATF1 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
P18846 LENRVAVLENQNKTLIEELKTLKDLYSNKSV
More detailsWildtype Residue : R Mutant Position : 228 Mutant label : p.R228G Feature Name :UNIPROTKB_P18846_CONFLICT_227_227( 227- 227 ) | |||||||
Pathways Affected
This tab displays a table of pathways affected by the mutation
[more details]
| Source | Pathways |
|---|---|
| Reactome | [2 processes]: Signaling in Immune system; Signalling by NGF |
| WikiPathway | IL-3 Signaling Pathway |
| WikiPathway | Myometrial Relaxation and Contraction Pathways |
| WikiPathway | EGFR1 Signaling Pathway |
| WikiPathway | Serotonin Receptor 4/6/7 -> NR3C signaling |
References
This tab displays a table of references for the mutation
[more details]
| Reference Title | Author | Year | Journal | Status | COSMIC | Pubmed |
|---|