Cosmic » Mutation » Overview » KRAS »p.Q22K / c.64C>A
This tab shows an overview of the mutation data
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This tab displays the distribution of mutated samples and tissue types.
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This tab displays a table of muated samples, with tissue, histology and zygosity information.
Publication information is also included, where available, with links to PUBMED.
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| Sample name | Gene name | Transcript | Primary Tissue | Histology | Pubmed ID | Zygosity | Somatic Status |
|---|
This tab displays a table of protein features
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| View | Identifier | Source | Feature | Start | End | Status | Score |
|---|---|---|---|---|---|---|---|
| P01116 | G3DSA:3.40.50.300 | G3DSA:3.40.50.300 | 3 | 165 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :G3DSA:3.40.50.300( 3- 165 ) | |||||||
| P01116 | Ras | Ras | 5 | 164 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :Ras( 5- 164 ) | |||||||
| P01116 | RASTRNSFRMNG | RASTRNSFRMNG | 4 | 25 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :RASTRNSFRMNG( 4- 25 ) | |||||||
| P01116 | RAS | RAS | 1 | 189 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :RAS( 1- 189 ) | |||||||
| P01116 | PTHR24070:SF54 | PTHR24070:SF54 | 1 | 189 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :PTHR24070:SF54( 1- 189 ) | |||||||
| P01116 | PTHR24070 | PTHR24070 | 1 | 189 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :PTHR24070( 1- 189 ) | |||||||
| P01116 | RAS | RAS | 1 | 166 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :RAS( 1- 166 ) | |||||||
| P01116 | SSF52540 | SSF52540 | 3 | 185 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :SSF52540( 3- 185 ) | |||||||
| P01116 | small_GTP | small_GTP | 1 | 159 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :small_GTP( 1- 159 ) | |||||||
| P01116 | UniProt:curator | GTPase KRas | 1 | 186 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :GTPase KRas( 1- 186 ) | |||||||
| P01116 | UniProt:curator | GTPase KRas, N-terminally processed | 2 | 186 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :GTPase KRas, N-terminally processed( 2- 186 ) | |||||||
| P01116 | PubMed:17056636 | UNIPROTKB_P01116_VARIANT_22_22 | 22 | 22 | Proximity | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :UNIPROTKB_P01116_VARIANT_22_22( 22- 22 ) | |||||||
| P01116 | PubMed:17056636 | UNIPROTKB_P01116_VARIANT_22_22 | 22 | 22 | Proximity | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :UNIPROTKB_P01116_VARIANT_22_22( 22- 22 ) | |||||||
| P01116 | UniProt:curator | UNIPROTKB_P01116_HELIX_16_25 | 16 | 25 | Overlap | 90.43 | |
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KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : Q Mutant Position : 22 Mutant label : p.Q22K Feature Name :UNIPROTKB_P01116_HELIX_16_25( 16- 25 ) | |||||||
This tab displays a table of pathways affected by the mutation
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| Source | Pathways |
|---|---|
| Reactome | [6 processes]: Axon guidance; Hemostasis; Signaling by EGFR; Signaling by Insulin receptor; Signaling by PDGF; Signalling by NGF |
| WikiPathway | IL-5 Signaling Pathway |
| WikiPathway | IL-3 Signaling Pathway |
| WikiPathway | MAPK signaling pathway |
| WikiPathway | G Protein Signaling Pathways |
| WikiPathway | MAPK Cascade |
| WikiPathway | EGFR1 Signaling Pathway |
| WikiPathway | Regulation of Actin Cytoskeleton |
| WikiPathway | IL-2 Signaling Pathway |
| WikiPathway | ErbB signaling pathway |
This tab displays a table of references for the mutation
[more details]
| Reference Title | Author | Year | Journal | Status | COSMIC | Pubmed |
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