Cosmic » Mutation » Overview » IFNB1 » p.S96S / c.288T>C
Overview
This tab shows an overview of the mutation data [more details]
- Description:
- Mutation id:
- AA Mutation:
- CDS Mutation:
- GRCH 37:
- Cancer Genome Browser:
- CDD:
- Homologene:
- Ever confirmed somatic:
- IFNB1
- COSM51852
- p.S96S ( Substitution - coding silent )
- c.288T>C ( Substitution )
- Ensembl Contig View: 9: 21077581..21077581
- COSMIC GBrowse: 9: 21077581..21077581
- NP_002167.1
- 1640 , click here to look the multiple sequence alignment.
- Yes
Tissue Distribution
This tab displays the distribution of mutated samples and tissue types.
[more details]
Samples
This tab displays a table of muated samples, with tissue, histology and zygosity information.
Publication information is also included, where available, with links to PUBMED.
[more details]
| Sample name | Gene Name | Transcript | Primary Tissue | Histology | Pubmed Id | Zygosity | Somatic Status |
|---|
Protein features
This tab displays a table of protein features
[more details]
| View | Identifier | Source | Feature | Start | End | Status | Score |
|---|---|---|---|---|---|---|---|
| P01574 | G3DSA:1.20.1250.10 | G3DSA:1.20.1250.10 | 27 | 186 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :G3DSA:1.20.1250.10( 27- 186 ) | |||||||
| P01574 | Interferon | Interferon | 29 | 187 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :Interferon( 29- 187 ) | |||||||
| P01574 | INTERFERONAB | INTERFERONAB | 79 | 106 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :INTERFERONAB( 79- 106 ) | |||||||
| P01574 | PTHR11691:SF7 | PTHR11691:SF7 | 2 | 187 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :PTHR11691:SF7( 2- 187 ) | |||||||
| P01574 | PTHR11691 | PTHR11691 | 2 | 187 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :PTHR11691( 2- 187 ) | |||||||
| P01574 | IFabd | IFabd | 58 | 175 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :IFabd( 58- 175 ) | |||||||
| P01574 | 4_helix_cytokine | 4_helix_cytokine | 22 | 187 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :4_helix_cytokine( 22- 187 ) | |||||||
| P01574 | UniProt:curator | Interferon beta | 22 | 187 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :Interferon beta( 22- 187 ) | |||||||
| P01574 | PubMed:6162107 | UNIPROTKB_P01574_DISULFID_52_162 | 52 | 162 | Overlap | 100.00 | |
|
IFNB1 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
P01574 MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFD 60
IFNB1 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
P01574 IPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLK 120
IFNB1 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
P01574 TVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINR 180
IFNB1 LTGYLRN
P01574 LTGYLRN
More detailsWildtype Residue : S Mutant Position : 96 Mutant label : p.S96S Feature Name :UNIPROTKB_P01574_DISULFID_52_162( 52- 162 ) | |||||||
Pathways Affected
This tab displays a table of pathways affected by the mutation
[more details]
| Source | Pathways |
|---|---|
| Reactome | |
| WikiPathway | Osteoclast |
| WikiPathway | Regulation of toll-like receptor signaling pathway |
| WikiPathway | EBV LMP1 signaling |
| WikiPathway | Cytokines and Inflammatory Response (BioCarta) |
| WikiPathway | Type II interferon signaling (IFNG) |
| WikiPathway | Senescence and Autophagy |
| WikiPathway | Toll-like receptor signaling pathway |
References
This tab displays a table of references for the mutation
[more details]
| Reference Title | Author | Year | Journal | Status | COSMIC | Pubmed |
|---|