Cosmic » Mutation » Overview » KRAS » p.T74P / c.220A>C
Overview
This tab shows an overview of the mutation data [more details]
- Description:
- Mutation id:
- AA Mutation:
- CDS Mutation:
- NCBI 36:
- GRCH 37:
- Cancer Genome Browser:
- CDD:
- Ever confirmed somatic:
- KRAS
- COSM28672
- p.T74P ( Substitution - Missense )
- c.220A>C ( Substitution )
- Ensembl Contig View: 12: 25271505..25271505
- Ensembl Contig View: 12: 25380238..25380238
- COSMIC GBrowse: 12: 25380238..25380238
- NP_203524.1
- No
Tissue Distribution
This tab displays the distribution of mutated samples and tissue types.
[more details]
Samples
This tab displays a table of muated samples, with tissue, histology and zygosity information.
Publication information is also included, where available, with links to PUBMED.
[more details]
| Sample name | Gene Name | Transcript | Primary Tissue | Histology | Pubmed Id | Zygosity | Somatic Status |
|---|
Protein features
This tab displays a table of protein features
[more details]
| View | Identifier | Source | Feature | Start | End | Status | Score |
|---|---|---|---|---|---|---|---|
| P01116 | G3DSA:3.40.50.300 | G3DSA:3.40.50.300 | 3 | 165 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :G3DSA:3.40.50.300( 3- 165 ) | |||||||
| P01116 | Ras | Ras | 5 | 164 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :Ras( 5- 164 ) | |||||||
| P01116 | RAS | RAS | 1 | 189 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :RAS( 1- 189 ) | |||||||
| P01116 | PTHR24070:SF54 | PTHR24070:SF54 | 1 | 189 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :PTHR24070:SF54( 1- 189 ) | |||||||
| P01116 | PTHR24070 | PTHR24070 | 1 | 189 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :PTHR24070( 1- 189 ) | |||||||
| P01116 | RAS | RAS | 1 | 166 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :RAS( 1- 166 ) | |||||||
| P01116 | SSF52540 | SSF52540 | 3 | 185 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :SSF52540( 3- 185 ) | |||||||
| P01116 | small_GTP | small_GTP | 1 | 159 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :small_GTP( 1- 159 ) | |||||||
| P01116 | UniProt:curator | GTPase KRas | 1 | 186 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :GTPase KRas( 1- 186 ) | |||||||
| P01116 | UniProt:curator | GTPase KRas, N-terminally processed | 2 | 186 | Overlap | 90.43 | |
|
KRAS MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
P01116 MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG 60
KRAS QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
P01116 QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL 120
KRAS PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHK.EKMSKDGKKKKK 180
P01116 PSRTVDTKQAQDLARSYGIPFIETSAKTRQRVEDAFYTLVREIRQYRLKKISKEEKTPGC 180
KRAS KSKTKCVIM
P01116 VKIKKCIIM
More detailsWildtype Residue : T Mutant Position : 74 Mutant label : p.T74P Feature Name :GTPase KRas, N-terminally processed( 2- 186 ) | |||||||
Pathways Affected
This tab displays a table of pathways affected by the mutation
[more details]
| Source | Pathways |
|---|---|
| Reactome | [6 processes]: Axon guidance; Hemostasis; Signaling by EGFR; Signaling by Insulin receptor; Signaling by PDGF; Signalling by NGF |
| WikiPathway | IL-5 Signaling Pathway |
| WikiPathway | IL-3 Signaling Pathway |
| WikiPathway | MAPK signaling pathway |
| WikiPathway | G Protein Signaling Pathways |
| WikiPathway | MAPK Cascade |
| WikiPathway | EGFR1 Signaling Pathway |
| WikiPathway | Regulation of Actin Cytoskeleton |
| WikiPathway | IL-2 Signaling Pathway |
| WikiPathway | ErbB signaling pathway |
References
This tab displays a table of references for the mutation
[more details]
| Reference Title | Author | Year | Journal | Status | COSMIC | Pubmed |
|---|