Cosmic » Mutation » Overview » RASD2 »p.A199T / c.595G>A

This tab shows an overview of the mutation data [more details]
Gene Name:
RASD2
Mutation Id:
COSM21666
AA Mutation:
p.A199T ( Substitution - Missense )
CDS Mutation:
c.595G>A ( Substitution )
GRCh37:
Ensembl Contig View 22:35947868..35947878
Cancer Genome Browser:
COSMIC GBrowse 22:35947868..35947878
CDD:
NP_055125.2
Homologene:
8628, click hereto look at the multiple sequence alignment.
Ever confirmed somatic:
Yes
This tab displays the distribution of mutated samples and tissue types. [more details]
This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene name Transcript Primary Tissue Histology Pubmed ID Zygosity Somatic Status
This tab displays a table of protein features [more details]
View Identifier Source Feature Start End Status Score
Q96D21 RAS RAS 15 266 Overlap 100.00
RASD2 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 Q96D21 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 RASD2 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 Q96D21 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 RASD2 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 Q96D21 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 RASD2 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 Q96D21 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 RASD2 NSDLKYIKAKVLREGQARERDKCTIQ Q96D21 NSDLKYIKAKVLREGQARERDKCTIQ

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Wildtype Residue : A Mutant Position : 199 Mutant label : p.A199T Feature Name :RAS( 15- 266 )
Q96D21 PTHR24070:SF90 PTHR24070:SF90 1 266 Overlap 100.00
RASD2 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 Q96D21 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 RASD2 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 Q96D21 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 RASD2 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 Q96D21 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 RASD2 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 Q96D21 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 RASD2 NSDLKYIKAKVLREGQARERDKCTIQ Q96D21 NSDLKYIKAKVLREGQARERDKCTIQ

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Wildtype Residue : A Mutant Position : 199 Mutant label : p.A199T Feature Name :PTHR24070:SF90( 1- 266 )
Q96D21 PTHR24070 PTHR24070 1 266 Overlap 100.00
RASD2 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 Q96D21 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 RASD2 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 Q96D21 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 RASD2 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 Q96D21 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 RASD2 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 Q96D21 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 RASD2 NSDLKYIKAKVLREGQARERDKCTIQ Q96D21 NSDLKYIKAKVLREGQARERDKCTIQ

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Wildtype Residue : A Mutant Position : 199 Mutant label : p.A199T Feature Name :PTHR24070( 1- 266 )
Q96D21 SSF52540 SSF52540 15 203 Overlap 100.00
RASD2 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 Q96D21 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 RASD2 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 Q96D21 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 RASD2 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 Q96D21 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 RASD2 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 Q96D21 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 RASD2 NSDLKYIKAKVLREGQARERDKCTIQ Q96D21 NSDLKYIKAKVLREGQARERDKCTIQ

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Wildtype Residue : A Mutant Position : 199 Mutant label : p.A199T Feature Name :SSF52540( 15- 203 )
Q96D21 UniProt:curator GTP-binding protein Rhes 1 263 Overlap 100.00
RASD2 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 Q96D21 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 RASD2 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 Q96D21 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 RASD2 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 Q96D21 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 RASD2 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 Q96D21 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 RASD2 NSDLKYIKAKVLREGQARERDKCTIQ Q96D21 NSDLKYIKAKVLREGQARERDKCTIQ

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Wildtype Residue : A Mutant Position : 199 Mutant label : p.A199T Feature Name :GTP-binding protein Rhes( 1- 263 )
Q96D21 UniProt:curator Interaction with GNB1, GNB2 and GNB3 189 235 Overlap 100.00
RASD2 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 Q96D21 MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVY 60 RASD2 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 Q96D21 NIRGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVK 120 RASD2 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 Q96D21 SCLKNKTKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVD 180 RASD2 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 Q96D21 EMFYVLFSMAKLPHEMSPALHRKISVQYGDAFHPRPFCMRRVKEMDAYGMVSPFARRPSV 240 RASD2 NSDLKYIKAKVLREGQARERDKCTIQ Q96D21 NSDLKYIKAKVLREGQARERDKCTIQ

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Wildtype Residue : A Mutant Position : 199 Mutant label : p.A199T Feature Name :Interaction with GNB1, GNB2 and GNB3( 189- 235 )
This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed