Mutation Overview - SIAH1 - p.R124R(Substitution - coding silent)

Cosmic » Mutation » Overview » SIAH1 » p.R124R / c.370A>C

Overview

This tab shows an overview of the mutation data [more details]
  • Description:
  • Mutation id:
  • AA Mutation:
  • CDS Mutation:
  • GRCH 37:
  • Cancer Genome Browser:
  • CDD:
  • Ever confirmed somatic:

Tissue Distribution

This tab displays the distribution of mutated samples and tissue types. [more details]

Samples

This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene Name Transcript Primary Tissue Histology Pubmed Id Zygosity Somatic Status

Protein features

This tab displays a table of protein features [more details]
View Identifier Source Feature Start End Status Score
Q8IUQ4 G3DSA:3.90.890.10 G3DSA:3.90.890.10 106 148 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :G3DSA:3.90.890.10( 106- 148 )
Q8IUQ4 Sina Sina 82 278 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :Sina( 82- 278 )
Q8IUQ4 ZF_SIAH ZF_SIAH 93 153 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :ZF_SIAH( 93- 153 )
Q8IUQ4 PTHR10315:SF11 PTHR10315:SF11 33 282 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :PTHR10315:SF11( 33- 282 )
Q8IUQ4 PTHR10315 PTHR10315 33 282 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :PTHR10315( 33- 282 )
Q8IUQ4 Traf_like Traf_like 93 282 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :Traf_like( 93- 282 )
Q8IUQ4 UniProt:curator E3 ubiquitin-protein ligase SIAH1 1 282 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :E3 ubiquitin-protein ligase SIAH1( 1- 282 )
Q8IUQ4 UniProt:curator SIAH-type 93 153 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :SIAH-type( 93- 153 )
Q8IUQ4 UniProt:curator SBD 90 282 Overlap 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :SBD( 90- 282 )
Q8IUQ4 UniProt:curator Zinc 1 121 121 Proximity 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :Zinc 1( 121- 121 )
Q8IUQ4 UniProt:curator Zinc 2 128 128 Proximity 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :Zinc 2( 128- 128 )
Q8IUQ4 UniProt:curator UNIPROTKB_Q8IUQ4_MUTAGEN_124_124 124 124 Proximity 99.29
SIAH1 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 Q8IUQ4 MSRQTATALPTGTSKCPPSQRVPALTGTTASNNDLASLFECPVCFDYVLPPILQCQSGHL 60 SIAH1 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 Q8IUQ4 VCSNCRPKLTCCPTCRGPLGSIRNLAMEKVANSVLFPCKYASSGCEITLPHTEKADHEEL 120 SIAH1 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLSGAVDWVM 180 Q8IUQ4 CEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVM 180 SIAH1 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 Q8IUQ4 MQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATP 240 SIAH1 RSIHGGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC Q8IUQ4 RSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC

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Wildtype Residue : R Mutant Position : 124 Mutant label : p.R124R Feature Name :UNIPROTKB_Q8IUQ4_MUTAGEN_124_124( 124- 124 )

References

This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed