Mutation Overview - PPM1E - p.G332R(Substitution - Missense)

Cosmic » Mutation » Overview » PPM1E » p.G332R / c.994G>A

Overview

This tab shows an overview of the mutation data [more details]
  • Description:
  • Mutation id:
  • AA Mutation:
  • CDS Mutation:
  • GRCH 37:
  • Cancer Genome Browser:
  • CDD:
  • Homologene:
  • Ever confirmed somatic:

Tissue Distribution

This tab displays the distribution of mutated samples and tissue types. [more details]

Samples

This tab displays a table of muated samples, with tissue, histology and zygosity information. Publication information is also included, where available, with links to PUBMED. [more details]
Sample name Gene Name Transcript Primary Tissue Histology Pubmed Id Zygosity Somatic Status

Protein features

This tab displays a table of protein features [more details]
View Identifier Source Feature Start End Status Score
PF00481 Pfam PP2C:239-490 239 490 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

More details

Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PP2C:239-490( 239- 490 )
Q8WY54 G3DSA:3.60.40.10 G3DSA:3.60.40.10 235 501 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

More details

Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :G3DSA:3.60.40.10( 235- 501 )
Q8WY54 PP2C PP2C 242 490 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

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Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PP2C( 242- 490 )
Q8WY54 PTHR13832:SF88 PTHR13832:SF88 112 600 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

More details

Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PTHR13832:SF88( 112- 600 )
Q8WY54 PTHR13832 PTHR13832 112 600 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

More details

Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PTHR13832( 112- 600 )
Q8WY54 PP2C_SIG PP2C_SIG 255 497 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

More details

Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PP2C_SIG( 255- 497 )
Q8WY54 PP2Cc PP2Cc 228 495 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

More details

Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PP2Cc( 228- 495 )
Q8WY54 PP2C-related PP2C-related 219 502 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

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Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PP2C-related( 219- 502 )
Q8WY54 UniProt:curator Protein phosphatase 1E 1 764 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

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Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :Protein phosphatase 1E( 1- 764 )
Q8WY54 UniProt:curator PP2C-like 255 497 Overlap 99.87
PPM1E MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPE..PEPEPEPEPESEPEPEPELVEAEA 60 Q8WY54 MAGCIPEEKTYRRFLELFLGEFRGPCGGGEPEPEPEPEPEPEPEPESEPEPEPELVEAEA 60 PPM1E AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 Q8WY54 AEASVEEPGEEAATVAATEEGDQEQDPEPEEEAAVEGEEEEEGAATAAAAPGHSAVPPPP 120 PPM1E PQLPPLPPL.........PRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 Q8WY54 PQLPPLPPLPRPLSERITPRPLSERITREEVEGESLDLCLQQLYKYNCPSFLAAALARAT 180 PPM1E SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 Q8WY54 SDEVLQSDLSAHYIPKETDGTEGTVEIETVKLARSVFSKLHEICCSWVKDFPLRRRPQLY 240 PPM1E YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 Q8WY54 YETSIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQEEQAYFAVFDGHGGVDAAIYASIHLH 300 PPM1E VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 Q8WY54 VNLVRQEMFPHDPAEALCRAFRVTDERFVQKAARESLRCGTTGVVTFIRGNMLHVAWVGD 360 PPM1E SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVVWFGAWRVNGSLSVSRAIGDAEHK 420 Q8WY54 SQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCIVWFGAWRVNGSLSVSRAIGDAEHK 420 PPM1E PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 Q8WY54 PYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKENNGDSSMVAHKLV 480 PPM1E ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 Q8WY54 ASARDAGSSDNITVIVVFLRDMNKAVNVSEESDWTENSFQGGQEDGGDDKENHGECKRPW 540 PPM1E PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 Q8WY54 PQHQCSAPADLGYDGRVDSFTDRTSLSPGSQINVLEDPGYLDLTQIEASKPHSAQFLLPV 600 PPM1E EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 Q8WY54 EMFGPGAPKKANLINELMMEKKSVQSSLPEWSGAGEFPTAFNLGSTGEQIYRMQSLSPVC 660 PPM1E SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 Q8WY54 SGLENEQFKSPGNRVSRLSHLRHHYSKKWHRFRFNPKFYSFLSAQEPSHKIGTSLSSLTG 720 PPM1E SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE Q8WY54 SGKRNRIRSSLPWRQNSWKGYSENMRKLRKTHDIPCPDLPWSYKIE

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Wildtype Residue : G Mutant Position : 343 Mutant label : p.G332R Feature Name :PP2C-like( 255- 497 )

References

This tab displays a table of references for the mutation [more details]
Reference Title Author Year Journal Status COSMIC Pubmed