This tab shows a graphical representation of the selected gene in JBrowse and a general overview of the information available for the gene. [more details]
Gene name
BRAF
This is a known cancer gene, for more information please look here
Genomic Coordinates
7:140434397..140624503
Gene Id
COSG2
Synonyms
B-raf 1,B-raf1,BRAF1,MGC126806,MGC138284,RAFB1,CCDS5863.1,P15056,ENSG00000157764
Drug Sensitivity Data:
Mutations in BRAF are associated with altered sensitivity to the following drug(s) : AZD6482, Gefitinib, PLX4720, Nutlin-3a, AZ628, Bortezomib, Embelin, RDEA119, FH535, CI-1040, CHIR-99021, AP-24534, Obatoclax Mesylate, PF-562271, CEP-701, FTI-277, 17-AAG, PD-0325901, SB590885, AZD6244, PD-173074, ZM-447439, BIBW2992, Temsirolimus, Metformin, AZ628, Nutlin-3a, AZD6244, PLX4720, PD-0325901, ZM-447439, SB590885, 17-AAG, Embelin, FH535, RDEA119, CI-1040, CHIR-99021, AP-24534, ABT-888, Obatoclax Mesylate, PF-562271, AICAR, FTI-277, Docetaxel, BIBW2992, GDC0941, AZD6482, Axitinib
Click here for all BRAF drug sensitivity data
No.of Samples
Total number of unique samples: 205811
Unique samples with mutations: 40105
Mouse mutagenesis
Mouse insertional mutagenesis experiments support BRAF as a cancer causing gene, please click
for more information.
cDNA Sequence
ENST00000288602
Protein Sequence
BRAF
Transcript and Protein Aligned
ENST00000288602+BRAF
This tab shows gene fusions involving the selected gene. [more details]
BRAF is involved in fusions with :
AGTRAP ( 1 mutations in 1 samples )
AKAP9_ENST00000356239 ( 4 mutations in 292 samples )
CLCN6 ( 1 mutations in 96 samples )
FAM131B_ENST00000443739 ( 6 mutations in 107 samples )
FCHSD1 ( 1 mutations in 2 samples )
GNAI1 ( 1 mutations in 96 samples )
KIAA1549 ( 593 mutations in 1325 samples )
MKRN1 ( 1 mutations in 96 samples )
RNF130 ( 2 mutations in 96 samples )
SLC45A3 ( 1 mutations in 6 samples )
This tab shows studies associated with the selected gene. [more details]
This tab shows publications associated with the selected gene. [more details]
Reference Title Author Year Journal Status COSMIC Pubmed

Cosmic Genome Browser

Mutation Analysis

Distribution

histogram image

External Links