This tab shows a graphical representation of the selected gene in JBrowse and a general overview of the information available for the gene. [more details]
Gene name
ALK
This is a known cancer gene, for more information please look here
Genomic Coordinates
2:29416090..30143525
Gene Id
COSG50
Synonyms
CD246,TFG/ALK,Q9UM73,ENSG00000171094
Drug Sensitivity Data:
Mutations in ALK are associated with altered sensitivity to the following drug(s) : Roscovitine, GW 441756, Methotrexate, CEP-701, ATRA, SB 216763, ABT-263, PD-0332991, JNK Inhibitor VIII, Vinorelbine, 17-AAG, ZM-447439, BIRB 0796, AZ628, PF-02341066, AZ628, PF-02341066, Elesclomol, ZM-447439, PD-0332991, Methotrexate, Vorinostat, AZD-2281, AZD7762, CEP-701, SB 216763, Roscovitine
Click here for ALK all drug sensitivity data
No.of Samples
Total number of unique samples: 24920
Unique samples with mutations: 537
cDNA Sequence
ENST00000389048
Protein Sequence
ALK
Transcript and Protein Aligned
ENST00000389048+ALK
This tab shows gene fusions involving the selected gene. [more details]
ALK is involved in fusions with :
ATIC ( 12 mutations in 99 samples )
C2orf44 ( 1 mutations in 1 samples )
CARS ( 3 mutations in 4 samples )
CLTC ( 26 mutations in 173 samples )
EML4 ( 582 mutations in 9742 samples )
FN1 ( 1 mutations in 1 samples )
KIF5B ( 8 mutations in 2176 samples )
KLC1 ( 1 mutations in 301 samples )
MSN ( 2 mutations in 2 samples )
NPM1 ( 319 mutations in 1344 samples )
PPFIBP1 ( 3 mutations in 3 samples )
RANBP2 ( 18 mutations in 28 samples )
SEC31A ( 1 mutations in 1 samples )
SQSTM1 ( 1 mutations in 1 samples )
STRN ( 5 mutations in 172 samples )
TFG ( 5 mutations in 340 samples )
TPM3 ( 21 mutations in 193 samples )
TPM4 ( 6 mutations in 27 samples )
VCL ( 2 mutations in 2 samples )
This tab shows studies associated with the selected gene. [more details]
This tab shows publications associated with the selected gene. [more details]
Reference Title Author Year Journal Status COSMIC Pubmed

Cosmic Genome Browser

Mutation Analysis

Distribution

histogram image

External Links