GRCh38 · COSMIC v83

Gene view

The gene view histogram is a graphical view of mutations across EWSR1. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Show more

This default peptide view shows a histogram of single base substitutions, colour coded by residue according to the colour scheme used in Ensembl. Under this is shown the amino acid sequence and the Pfam protein structures, followed by complex mutations and insertions and deletions. The graphical view can be switched to cDNA coordinates by selecting from the "Coordinate system" options in the "Filters" panel on the left.

You can use the filters panel to select the types of data that are displayed. After adjusting a filter, press Apply filters, or press Reset filters to revert to the original, unfiltered display.

You can see more information on the help pages.



This section gives an overview of EWSR1, along with links to any related data and resources.

Census gene
This is a known cancer gene, from Tier 1 of the Cancer Gene Census. Tier 1 genes have documented evidence of their relevance to cancer.
Curated gene
This is NOT an expert curated gene.
Mouse gene
Mouse insertional mutagenesis experiments support the designation of EWSR1 as a cancer causing gene.
More information
This gene has a cancer hallmark. You can see more information about hallmarks.
EWSR1 (COSG1541)
Genomic coordinates
22:29268337..29300161  (positive strand)
EWS, CCDS13851.1, ENSG00000182944
There is 1 structure for EWSR1. View it in COSMIC-3D.
Number of samples
44712 unique samples
205 unique samples with mutations
Alternative transcripts
EWSR1_ENST00000333395, EWSR1_ENST00000414183
You can see various sequences for this gene:
cDNA (ENST00000397938)
Protein (EWSR1)
Transcript and protein aligned (ENST00000397938+EWSR1)
Gene fusions
EWSR1 is involved in 20 fusions, with the following genes:
  • FLI1 (1332 mutations in 2132 samples)
  • ATF1 (179 mutations in 357 samples)
  • ERG (122 mutations in 1639 samples)
  • WT1 (121 mutations in 267 samples)
  • NR4A3 (85 mutations in 176 samples)
  • CREB1 (28 mutations in 85 samples)
  • DDIT3 (26 mutations in 344 samples)
  • POU5F1 (10 mutations in 73 samples)
  • FEV (6 mutations in 92 samples)
  • PBX1 (6 mutations in 67 samples)
  • ETV1 (4 mutations in 65 samples)
  • NFATC2 (4 mutations in 4 samples)
  • ETV4 (3 mutations in 66 samples)
  • ZNF444_ENST00000337080 (2 mutations in 67 samples)
  • YY1 (2 mutations in 16 samples)
  • ZNF384 (2 mutations in 2 samples)
  • NFATC1 (1 mutation in 1 sample)
  • PATZ1 (1 mutation in 1 sample)
  • SMARCA5 (1 mutation in 1 sample)
  • SP3 (1 mutation in 1 sample)
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Drug sensitivity data

Drug resistance

This section shows the drugs that have been used to treat EWSR1 mutant tumours. In the tabs below you can see any other genes that have been treated with the same drug(s), and the distribution of mutations that occur in those genes.


Tissue distribution

The table shows the distribution of mutations across the primary tissue types that are curated by COSMIC. Histograms show the percentage of mutated samples for point mutations, CNV data and gene expression data. Moving your mouse over the histograms will show additional data.

You can see additional information about the data presented here in the help pages.


Genome browser

Note that you can also view the genome browser in a separate page.

The genome browser shows COSMIC annotations for EWSR1 in a genomic context. Show more

Note: in some web browsers the genome browser may display a blank content panel when switching between browser tabs or when returning to the page using the browser's Back button. If this happens please click and drag the blank content panel to reload the genome browser.


Mutation distribution

This section displays a series of charts that show the distribution of different types of mutations for EWSR1. Show more

The first chart in this section shows a summary of the types of mutation that have been observed in samples for this gene. The table shows the number of samples recorded as having a particular type of mutation, with the number in brackets giving the percentage of samples with that type of mutation.

Note that a sample may have more than one type of mutation, so the total number of samples determined by simply summing the values in the table may not match the total number of unique samples given under the table. For the same reason, summing the percentages in the table may give a value of greater than 100%.

You can see additional information about this data in the help pages.



This tab displays a table of mutations for the selected gene. You can see more information in our help pages.

Position (AA) Mutation (CDS) Mutation (Amino Acid) Mutation ID (COSM) Count Mutation Type

This tab displays a table of fusions for the selected gene. You can see more information in our help pages.

Mutation (Amino Acid) Mutation ID (COSF) Count Mutation Type

This tab shows a table of gene expression and copy number variation (CNV) data for the selected gene with links to Sample, Study, CNV and (icons) to the ChromoView page (to view CNVs across the whole chromosome), the COSMIC Genome Browser and Ensembl. You can see more information in our help pages.

Table Information


The table currently shows only high value (numeric) copy number data. Copy number segments are excluded if the total copy number and minor allele values are unknown.

Click here to include all copy number data. For more detailed information about copy number data and gain/loss definitions click here.

Sample Expression Expr Level (Z-Score)

Over Expressed; Z-Score > 2.0

Under Expressed; Z-Score < -2.0

Normal; Z-Score within the range -2.0 to 2.0

CN Type Minor Allele Copy Number CN Segment
Average Ploidy

1. N/A represents cases where average ploidy value is not available( mostly ICGC samples). For some TCGA samples where minor allele information is not available the average ploidy value could not be calculated.

2. For TCGA samples, Ascat algorithm is used to calculate the average ploidy.

3. For CGP samples, Picnic algorithm is used to calculate the average ploidy.

Study CNV

This page contains the complete Methylation data for the gene and filter selection(s). Each Methylation probe links to the COSMIC Genome Browser and Ensembl. You can see more information in out help pages.

Sample Name Sample ID Probe ID Probe Posn. Type

High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5

Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5

Level (Beta-Value) Normal Average Study


This section shows publications associated with EWSR1. You can see more information in our help pages.

Reference Title Author Year Journal Status COSMIC Pubmed