GRCh38 · COSMIC v98


This section shows a summary for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the Sanger Institute Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.

Ovarian kinase
Study ID
The most frequently represented domain in the catalogue of known human cancer genes is the protein kinase domain. Inhibition of mutant protein kinases has proven to be of remarkable utility in cancer treatment. In this study, the coding domains of the entire protein kinase gene family have been examined in a collection of ovarian carcinomas (77% serous carcinomas). 99 of the 518 kinase genes were mutated in at least one sample, producing a total of 126 mutations, the majority of which were missense events. No obvious mutation clusters were observed. PD0880a is a known mismatch repair defective tumour and accounted for almost half of mutations found in this study.