This section shows a summary for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the Sanger Institute Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.
- Study
- Colorectal kinase
- Study ID
- COSU28
- Description
- The most frequently represented domain in the catalogue of known human cancer genes is the protein kinase domain. Inhibition of mutant protein kinases has proven to be of remarkable utility in cancer treatment. In this study, the coding domains of the entire protein kinase gene family have been examined in a collection of large intestine adenocarcinomas. No major mutation clusters were observed, with the catalogue of largely missense mutations spread throughout 96 of the 518 genes tested; the most frequently observed mutation was BRAF p.V600E, found in 4 samples. Two mismatch repair deficient cancers were included in the series, PD1519a and PD1520a, with 24 and 53 mutations respectively. KRAS was analysed independently and the results are presented in the Colorectal additions study.