GRCh38 · COSMIC v99

Summary

This section shows a summary for the selected study (COSU identifier) or publication (COSP identifier). Studies may have been performed by the Sanger Institute Cancer Genome Project, or imported from the ICGC/TCGA. You can see more information on the help pages.

Study
Somatic mutations of the protein kinase gene family in human lung cancer.
Study ID
COSU22
Description
Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. In this study, the coding domains of the entire protein kinase gene family (518 genes) have been examined in a collection of lung carcinomas. No commonly mutated kinase domain was found; the mutations were widely spread, mostly missense events with a probable majority of passenger mutations. The mutational spectra of most samples were characterized by a high proportion of C:G > A:T transversions, compatible with the mutagenic effects of tobacco carcinogens. Six samples were observed with more than 10 mutations, with NCI-H1770 the most hypermutable, presenting 49 mutations in this collection of 518 genes. This data is previously published.