GRCh38 · COSMIC v92

Summary

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Reference
Molecular heterogeneity characterizes glioblastoma with lipoblast/adipocyte-like cytology.
Paper ID
COSP39638
Authors
Gessi M, Gielen GH, Denkhaus D, Antonelli M, Giangaspero F, Zur Mühlen A, Japp AS and Pietsch T
Affiliation
Institute of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Straße 25, 53127, Bonn, Germany, mgessimd@yahoo.com.
Journal
Virchows Archiv : an international journal of pathology, 2015
ISSN: 1432-2307
PMID: 25896447 (view at PubMed or Europe PMC)
Abstract
Glioblastoma, the most common primary brain tumor in adults, may rarely show among unusual histological patterns lipoblast/adipocyte-like features. The genetic features of such cases are not yet well characterized, and molecular data are available for only few cases. In order to further expand our knowledge about their molecular profile, we analyzed four cases of glioblastoma with adipocyte-like features. Multiplex ligation-dependent probe amplification (MLPA) revealed loss of PTEN and MDM2 amplification in two cases while another case was characterized by CDKN2A deletion. Conversely, we did not find any evidence of EGFR amplification, BRAF (V600E) or IDH1/2 mutations. Our results, along with data published in previous studies, showed that glioblastoma with lipoblast/adipocyte-like cytology present a heterogeneous genetic background and therefore seem to represent more a rare phenotypic variant than a specific tumor subtype.
Paper Status
Curated