Cancer Gene Census
The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer.
The table below is generated from a working list of known cancer genes. The list has been annotated with information concerning chromosomal location, tumour types in which mutations are found, classes of mutation that contribute to oncogenesis and other genetic properties.
The table columns are as follows:
- Gene Symbol
- Name – descriptive name of the gene
- Entrez Gene ID – The ID links to the Entrez website
- Genome Location – GRCh38 location of the gene, with links to the genome browser and Ensembl
- Tier – indicates to which tier of the Cancer Gene Census the gene belongs
- Hallmark – indicates if a functional annotation for the gene is available and provides a link to the gene’s hallmarks-of-cancer page
- Chr Band – chromosome (1-22, X or Y), arm (p or q) and cytogenic band
-
Somatic – if
yes
, somatic mutations have been detected -
Germline – if
yes
, germline mutations have been detected - Tumour types (somatic) – somatic mutations in the gene are associated with the following diseases (see abbreviations tab)
- Tumour types (germline) – germline mutations in the gene are associated with the following diseases (see abbreviations tab)
- Cancer Syndrome – syndrome associated with germline mutation
- Tissue type – (see abbreviations tab)
- Molecular Genetics – (see abbreviations tab)
-
Role in Cancer –
oncogene
: hyperactivity of the gene drives the transformation;TSG
: loss of gene function drives the transformation. Some genes can play either of these roles depending on cancer type.Fusion
: the gene is known to be involved in oncogenic fusions. - Mutation Types – (see abbreviations tab)
- Translocation partner – gene symbol of fusion partner
- Other Germline Mut – other germline mutations not implicated in cancer
- Other Syndrome – other non-cancerous syndrome
- Synonyms – alternative names for the gene
Cancer Gene Census - Breakdown
These tables are generated from a working list of known cancer genes. The list has been annotated with information concerning chromosomal location, tumour types in which mutations are found, classes of mutation that contribute to oncogenesis and other genetic properties. We have sorted the data in a number of ways to list subsets of cancer genes with similar features. However, we would recommend that those wishing to scrutinise the list in detail should download it in its entirety from ten table in the 'Census' tab.
These tables can be searched, sorted or exported in csv or tsv formats.
Cancer Gene Census - Abbreviations
Glossary Terms
Hallmark
Based on the concept defined by D. Hanahan and R. A. Weinberg, COSMIC, in collaboration with Open Targets, integrates functional descriptions focused on Hallmarks of Cancer into the Cancer Gene Census. Hallmark pages visually explain the role of a gene in cancer by highlighting, which of the classic behaviours are displayed by the gene product and whether they are promoted or suppressed.
The 'switch view' toggle button allows to change the view between the hallmark ring and a table.
Descriptions include the role of cancer genes in 10 hallmarks of cancer as well as in cell division, differentiation, epigenetic regulation and senescence.
A concise overview with associated references is displayed in a panel on the right. References can be accessed directly for first hand verification and further investigation.
Help Index
- COSMIC
- Tutorials
- Cancer Browser::Overview
- Selection
- Genes::Top genes
- Genes::Genes with Mutations
- Genes::Genes without Mutations
- Mutation Matrix
- Distribution
- Variants::Fusions
- Variants::Mutations
- Variants::Methylation
- Variants::CNV & Expression
- Samples::Mutant Samples
- Samples::Non-Mutant Samples
- Cancer Gene Census
- CNV Overview
- CNV ChromoView
- CNV & Expr Details
- CONAN
- Fusion::Mutations
- Fusion::Overview
- Fusion::Summary
- Gene::Analysis
- Gene View
- Genome Browser
- Overview
- Tissues
- Distribution
- Drug Resistance::Genes
- Drug Resistance::Mutations
- Variants::Mutations
- Variants::Fusions
- Variants::CNV & Expr
- Variants::Methylation
- References
- Drug Resistance::Mutation Details
- Gene::Mutation Details
- Methylation Details
- Mutation::Overview
- Ncv::Overview
- Rearrangement::Overview
- Sample::Overview
- Circos
- Overview
- Variants::Fusions
- Variants::Mutations
- Variants::Breakpoints
- Variants::Non-Coding Mutation
- Variants::CNV & Expression
- Variants::Methylation
- Mutation Spectrum
- Sequence Context
- Heatmap
- Non-Mutant Genes
- References
- Study::Overview
- Papers::Page
- Downloading Data
- Legacy Downloads
- Beacon