GRCh38 · COSMIC v95
The gene view histogram is a graphical view of mutations across PDE4A. These mutations are displayed at the amino acid level across the full length of the gene by default. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Show more
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You can see more information on the help pages.
This section gives an overview of PDE4A, along with links to any related data and resources.
Census geneThis is NOT a known cancer gene. It is not found in the Cancer Gene Census.
Curated geneThis is NOT an expert curated gene.Mouse geneMouse insertional mutagenesis experiments DO NOT support the designation of PDE4A as a cancer causing gene.
More informationHallmark geneThis gene does not have a cancer hallmark. You can see more information about hallmarks.
- COSMIC gene
- PDE4A (COSG106039)
- Genomic coordinates
- 19:10420655..10469631 (positive strand)
- DPDE2, CCDS45961.1, P27815, ENSG00000065989.15, NM_001111307.1, NP_001104777
There are 5 structures for PDE4A. View them in COSMIC-3D.
- Number of samples
41177 unique samples
709 unique samples with mutations
- Alternative transcripts
- PDE4A_ENST00000440014, PDE4A_ENST00000293683, PDE4A_ENST00000592685, PDE4A_ENST00000344979
You can see various sequences for this gene:
Protein (PDE4A) Transcript and protein aligned (ENST00000380702.6+PDE4A)
- Gene fusions
- No fusions involving PDE4A
- Drug sensitivity data
This section shows the drugs associated with PDE4A resistance mutations. In the tabs below you can see any other genes that have resistance mutations to the same drug(s), and the distribution of mutations that occur in those genes.
You can see additional information about the data presented here in the help pages.
Note that you can also view the genome browser in a separate page.
The genome browser shows COSMIC annotations for PDE4A in a genomic context. Show more
This section displays a series of charts that show the distribution of different types of mutations for PDE4A. Show more
You can see additional information about this data in the help pages.
|Mutation (Amino Acid)||Mutation ID (COSF)||Count||Mutation Type|
|Sample||Expression||Expr Level (Z-Score)
Over Expressed; Z-Score > 2.0
Under Expressed; Z-Score < -2.0
Normal; Z-Score within the range -2.0 to 2.0
|CN Type||Minor Allele||Copy Number||CN Segment
2. For TCGA samples, Ascat algorithm is used to calculate the average ploidy.
3. For CGP samples, Picnic algorithm is used to calculate the average ploidy.
|Sample Name||Sample ID||Probe ID||Probe Posn.||Type
High (Hypermethylation); Beta-Value > 0.8 and differs from normal average by > 0.5
Low (Hypomethylated); Beta-Value < 0.2 and differs from normal average by > 0.5
|Level (Beta-Value)||Normal Average||Study|
This section shows publications associated with PDE4A. You can see more information in our help pages.
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