guardian of the genome [Pubmed]; Molecule of the Year 1993 [Pubmed]; transcription factor that coordinates cellular response to stress caused by a variety of signals including DNA damage, aberrant growth signalling, hypoxia, and a wide range of chemotherapeutic drugs, ultraviolet light, and protein-kinase inhibitors [Pubmed]; traffic cop at the crossroads of DNA repair and recombination [Pubmed]; maintains the integrity of mitochondrial DNA [Pubmed]