RECQL4

RecQ protein-like 4

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function summary function summary

DNA helicase, promotes ATP-dependent DNA unwinding [Pubmed]; plays primary role in DNA replication initiation [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, oncogene
cell division control cell division control depletion reduces origin firing efficiency, and suppresses cell proliferation [Pubmed]
types of alteration in cancer types of alteration in cancer amplification and high expression is associated with increased in vitro clonogenic survival and in vivo tumorigenicity in breast cancer [Pubmed]; amplified or overexpressed in breast cancer MDA-MB453 cell line [Pubmed]
genome instability and mutations genome instability and mutations
 
 

required for the efficient removal of UV lesions by NER [Pubmed]; regulates both directly and indirectly base excision repair capacity [Pubmed]; preserves mitochondrial DNA integrity [Pubmed]; participates in the NHEJ pathway of DSB repair via a functional interaction with the Ku70/Ku80 complex [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

KD leads to increased poly(ADP-ribose) polymerase (PARP) synthesis and induction of PARP-dependent apoptosis in prostate cancer [Pubmed]; physically interacts with a major survival factor-survivin and its protein level affects survivin expression, KD significantly inhibits the in vitro clonogenic survival and in vivo tumourigenicity in breast cancer MDA-MB453 cell line [Pubmed]

invasion and metastasis invasion and metastasis
 
 

KD reduces their cell invasiveness in vitro and tumorigenicity in vivo in prostate cancer [Pubmed]