PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

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function summary function summary

plays a critical role in microvascular repair following injury in endothelium [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer n/a
cell division control cell division control regulates S-phase entry [Pubmed]; modulation of PI3Kbeta activity alters the DNA replication rate by controlling proliferating cell nuclear antigen (PCNA) binding to chromatin and to DNA polymerase delta [Pubmed]
impact of mutation on function impact of mutation on function D1067V promoted PI3K pathway signalling, enhanced cell growth in vitro, and was sufficient for tumour formation in vivo [Pubmed]
genome instability and mutations genome instability and mutations
 
 

controls double-strand break DNA repair in kinase-independent way by regulation of the Nbs1 sensor protein binding to damaged DNA [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

when localised in the nucleus, suppresses apoptosis [Pubmed]