PDGFRA

platelet-derived growth factor, alpha-receptor

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function summary function summary

type III family transmembarne receptor tyrosine kinases (RTK), binds to all PDGF isoforms except PDGF-DD, signaling activates MAPK and RAS pathways [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer oncogene
differentiation and development differentiation and development inhibits differentiation by disrupting nuclear localisation and expression of TTF1 in papillary thyroid cancer [Pubmed]; PDGFRA signaling in progenitor cells promotes beige adipocyte commitment in adipocytes [Pubmed]
types of alteration in cancer types of alteration in cancer activating mutations in exons 12,14 and 18 identified in inflammatory fibroid polyps [Pubmed]; in fusion with multiple partners in haematological malignancies [Pubmed]; recurrent D842V, V561D, N659K, D842_H845del, I843_D846del [Pubmed]; range of activating mutations, amplification, gene fusions identified in breast cancer, GIST, melanoma, glioma [Pubmed]
impact of mutation on function impact of mutation on function D842V, D842_H845del, S566_E571delinsR result in constitutive, ligand-independent activation [Pubmed]
fusion partner fusion partner STRN in chronic eosinophilic leukaemia [Pubmed]; ETV6 in chronic eosinophilic leukaemia [Pubmed]; FOXP1 in myeloproliferative neoplasms [Pubmed]; FLP1L1 in myeloproliferative neoplasms [Pubmed]
clinical impact clinical impact expression correlates with lymph node metastasis in colorectal cancer [Pubmed]; high expression linked to lymph node involvement and recurrence in breast cancer [Pubmed]; germline activating mutations give rise to gastrointestinal stromal tumours (GIST) [Pubmed]
angiogenesis angiogenesis
 
 

overexpression inhibits angiogenesis in xenografts in melanoma [Pubmed]; promotes angiogenesis in endothelial cells [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

overexpression induces apoptosis in melanoma SK-MEL-110 cell line [Pubmed]

proliferative signalling proliferative signalling
 

KD suppresses tumour growth in vitro and in vivo in lung squamous cell carcinoma [Pubmed]

invasion and metastasis invasion and metastasis
 
 

overexpression promotes bone metastasis of xenografts in prostate cancer [Pubmed]; expression is assiociated with lympatic metastases in patients, signaling promotes migration and invasion in papillary thyroid cancer TPC-1, 8305C cell line [Pubmed]; receptor activation drives invadopodia formation, promotes cell migration, and upregulates EMT markers Snail and Snug in thyroid cancer B-CPAP cell line [Pubmed]; activating mutations including Y288C, P345S, V561D and D842V increase cell migration in breast cancer, GIST, melanoma, glioma [Pubmed]

suppression of growth suppression of growth
 

transient overexpression inhibits growth in vitro and in vivo in melanoma SK-MEL-28, A375, Preyer cell line [Pubmed]