PAX3

paired box gene 3

switch view
function summary function summary

transcription factor involved in regulation of migration of cells from the dorsal dermomyotome or neural crest during myogenesis, melanogenesis, and neurogenesis [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer fusion, oncogene
impact of mutation on function impact of mutation on function the fusion with MAML3 results in a phenotype characterized by aberrant expression of genes involved in neuroectodermal and myogenic differentiation, closely simulating the developmental roles of PAX3 [Pubmed]
fusion partner fusion partner FOXO1 in alveolar rhabdomyosarcoma [Pubmed]; NCOA1 in alveolar rhabdomyosarcoma [Pubmed]; NCOA2 in rhabdomyosarcoma [Pubmed]; MAML3 in sinonasal sarcoma [Pubmed]
escaping programmed cell death escaping programmed cell death
 
 

KD induces apoptosis [Pubmed]; inhibits apoptosis in brainstem progenitors [Pubmed]

proliferative signalling proliferative signalling
 

phosphorylation at Ser201 enhances the proliferative capacity of the metastatic cell line in melanoma [Pubmed]; in the absence of p53, Pax3 promotes proliferation in brainstem progenitors [Pubmed]

invasion and metastasis invasion and metastasis
 
 

KD decreases the attachment of neuroblastoma SH-EP1 cells to ECM proteins and inhibits cell migration and invasion [Pubmed]; the absence of phosphorylation at Ser205 promotes the invasive capacity of both primary and metastatic cells in melanoma [Pubmed]

suppression of growth suppression of growth
 

Pax3 phosphorylated at Ser209 inhibits the proliferative capacity of both primary and metastatic tumour cells in melanoma [Pubmed]