NRAS

neuroblastoma RAS viral (v-ras) oncogene homolog

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function summary function summary

a small GTPase that cycles between inactive GDP-bound and active GTP-bound conformations, regulates cellular responses to many extracellular stimuli, including soluble growth factors; NRAS is farnesylated at a terminal CAAX motif and additionally modified by palmitic acid residues just upstream of the CAAX motif to anchor the protein in the membrane [Pubmed]; has 5 naturally occurring isoforms with distinct binding affinities to known downstream targets and abilities to regulate the RAS signalling pathway [Pubmed]

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