nucleophosmin (nucleolar phosphoprotein B23, numatrin)

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function summary function summary

associates directly with rRNA gene chromatin as a histone chaperone and positively regulates transcription of rRNA in cervical cancer HeLa cell line [Pubmed]; binds to and regulates transcriptional activity of Myc, overexpression of NPM1 enhances MYC induced oncogene-mediated transformation in mouse fibroblast [Pubmed]; specifically recognizes and binds to DNA G-quadruplexes through its C-terminal region [Pubmed]; a histone chaperone with functions in DNA repair pathways, regulation of apoptosis and ribosome biogenesis [Pubmed]; one of the most commonly mutated genes in AML, more often associated with a normal karyotype in AML [Pubmed]

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