MED12

mediator complex subunit 12

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function summary function summary

promotes beta-catenin transactivation in response to Wnt signalling [Pubmed]; a subunit of the Mediator Complex regulating its activity in promoting gene transcription [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
types of alteration in cancer types of alteration in cancer highly recurrent G44D, G44S, G44V, a range of somatic mutations in exon 2 in breast phyllodes tumour [Pubmed]; highly recurrent G44D, G44S, G44V, a range of somatic mutations in exon 2 in leiomyoma [Pubmed]
impact of mutation on function impact of mutation on function exon 2 mutations in MED12 uncouple Cyclin C-CDK8/19 from core Mediator and implicate aberrant CDK8/19 activity [Pubmed]
genome instability and mutations genome instability and mutations
 
 

expression of G44D GOF variant is associated with development of chromosomal rearrangements in leiomyoma [Pubmed]

proliferative signalling proliferative signalling
 

plays a key role in the regulation of cell proliferation through the modulation of Wnt/?-catenin, and cell cycle-associated protein expression in leiomyoma [Pubmed]

invasion and metastasis invasion and metastasis
 
 

modulates TGF-beta-induced epithelial-mesenchymal transition signalling in colorectal cancer [Pubmed]