KRAS

v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog

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a small GTPase that cycles between inactive GDP-bound and active GTP-bound conformations, regulates cellular responses to many extracellular stimuli, including soluble growth factors, through PI3K, MEK/ERK and other pathways, the protein is farnesylated at a terminal CAAX motif and may be additionally modified by one or two palmitic acids just upstream of the CAAX motif to anchor the protein in the membrane; two isoforms occur in a cell as a result of alternative splicing at the C-terminus [Pubmed]

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