KDM6A

lysine (K)-specific demethylase 6A, UTX

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essential during normal development, required for correct reprogramming, embryonic development and tissue-specific differentiation [Pubmed]; histone 3 Lys27 (H3K27) demethylase, pro-oncogenic cofactor essential for leukaemia maintenance in TAL1-positive (but not TAL1-negative) T-ALL [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, oncogene
global regulation of gene expression global regulation of gene expression modulates H3K27 acetylation [Pubmed]; performs demethylation of H3K27 [Pubmed]
proliferative signalling proliferative signalling
 

KD resulted in significant decrease in the proliferation of cancer cells in vitro and in a mouse xenograft model in breast cancer [Pubmed]

invasion and metastasis invasion and metastasis
 
 

KD resulted in significant decrease of invasiveness of cancer cells in vitro and in a mouse xenograft model in breast cancer [Pubmed]; inhibits EMT-induced CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1 in breast cancer [Pubmed]