HNF1A

HNF1 homeobox A

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function summary function summary

transcription factor, important regulator of genes in liver, kidney, stomach and pancreatic islet cells [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
escaping programmed cell death escaping programmed cell death
 
 

KD results in a 30-40% reduced apoptosis in pancreatic cancer cell lines in pancreatic cancer [Pubmed]

invasion and metastasis invasion and metastasis
 
 

inhibition triggers epithelial-mesenchymal transition in hepatocellular carcinoma [Pubmed]

suppression of growth suppression of growth
 

KD results in a 2-fold higher rate of cell proliferation, 20% increased S phase and G2 phase cells in pancreatic cancer [Pubmed]