H3F3A

H3 histone, family 3A

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function summary function summary

a variant of H3 histone deposited into transcriptionally active regions to replace displaced nucleosomes throughout the cell cycle [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer oncogene
global regulation of gene expression global regulation of gene expression post-translational modifications of H3.3 have impact on transcriptional activity of multiple genes [Pubmed]
types of alteration in cancer types of alteration in cancer highly recurrent K28M, G35R in GBM [Pubmed]; recurrent G35W in bone giant cell tumour [Pubmed]
impact of mutation on function impact of mutation on function EZH2 mediated trimethylation of H3K27 is inhibited by K28M mutations in GBM [Pubmed]; K28M GOF mutant inhibits the enzymatic activity of the Polycomb repressive complex 2 through interaction with the EZH2 subunit [Pubmed]
No hallmarks No hallmarks