GNAS

guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1

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function summary function summary

G protein mediating the actions of many hormones, neurotransmitters, and paracrine/autocrine factors via generation of the second messenger cAMP [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, oncogene
types of alteration in cancer types of alteration in cancer highly recurrent R201C in pancreatic neoplasia [Pubmed]; highly recurrent R201C in pituitary adenoma [Pubmed]
impact of mutation on function impact of mutation on function R201C mutation results in the constitutive activation of GNAS and adenylate cyclase and leads to the autonomous synthesis of cyclic adenosine monophosphate (cAMP) [Pubmed]
proliferative signalling proliferative signalling
 

activation of adenylyl cyclase bypasses the cells' normal requirement for trophic hormone in pituitary adenoma [Pubmed]; GNAS R201C expression was associated with elevated expression of Wnt and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase (ERK1/2 MAPK) pathway target genes, increased phosphorylation of ERK1/2 MAPK and increased immunostaining for the proliferation marker Ki67 in mouse models [Pubmed]; promotes cell proliferation in RCC [Pubmed]

suppression of growth suppression of growth
 

suppresses Shh signalling-dependent cell proliferation by regulating both the cAMP-dependent pathway and ciliary trafficking of Hedgehog pathway components in Shh-driven medulloblastoma [Pubmed]