EZR

ezrin

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function summary function summary

ERM (ezrin-radixin-moesin) family protein taking part in linking the plasma membrane to the cortical actin cytoskeleton [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer fusion
fusion partner fusion partner ROS1 in lung adenocarcinoma [Pubmed]; ERBB4 in lung adenocarcinoma [Pubmed]
escaping programmed cell death escaping programmed cell death
 
 

negative regulator of death receptor-induced apoptosis in T-cells [Pubmed]

proliferative signalling proliferative signalling
 

overexpression inactivates NF2 tumour suppressor, enhancing cell proliferation and anchorage-independent growth in glioblastoma [Pubmed]

invasion and metastasis invasion and metastasis
 
 

induces EMT, downregulation suppresses tumour progression in cervical cancer [Pubmed]; enhances filopodia formation, contributing to the regulation of invasion and metastasis in oesophageal SCC [Pubmed]