EIF3E

eukaryotic translation initiation factor 3, subunit E

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function summary function summary

target of human T cell leukaemia virus type I Tax oncoprotein, which upon binding relocates EIF3E from the nucleus [Pubmed]; translation initiation factor necessary for eficient histone mRNA translation [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, fusion
fusion partner fusion partner RSPO2 in colon cancer [Pubmed]
angiogenesis angiogenesis
 
 

KD increases stability of HIF2A and induces agiogenesis in neuronal cells [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

silencing of EIF3E induces cell cycle arrest and apoptosis in glioblastoma [Pubmed]

proliferative signalling proliferative signalling
 

silencing of EIF3E decrease expression of HIF factors and cell proliferation in glioblastoma [Pubmed]

invasion and metastasis invasion and metastasis
 
 

decreased expression initiates ETM in breast epithelial cells [Pubmed]