EGFR

epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)

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function summary function summary

requires dimerisation for activity and downstream signalling [Pubmed]; receptor tyrosine kinase [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer oncogene
differentiation and development differentiation and development takes part in morphogenesis of epithelial organs including mammary glands [Pubmed]
types of alteration in cancer types of alteration in cancer frequently amplified, missense mutations and in frame deletions clustered within the extracellular domain result in constantly activated protein in glioblastoma [Pubmed]; frequently overexpressed in NSCLC [Pubmed]; recurrent L858R, E746delELREA, T790M, G719A, G719S, S768I [Pubmed]
impact of mutation on function impact of mutation on function mutations clustered within tyrosine kinase domain increase activity and delay inactivation of EGFR in NSCLC [Pubmed]; L858R causes abnormally high activity, primarily by promoting EGFR dimerisation through suppressing the disorder in the alphaC-helix region [Pubmed]; deletions in exon 19 cause truncation of the beta3-alphaC loop and restrain alphaC in an active "in" conformation, imparting resistance to inhibitors like vemurafenib that bind the alphaC "out" conformation [Pubmed]
angiogenesis angiogenesis
 
 

activation of the EGFR pathway is involved in tumour associated angiogenesis [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

activation of EGFR protects against anoikis [Pubmed]; activating mutations within the tyrosine kinase domain activate anti-apoptotic pathways [Pubmed]

proliferative signalling proliferative signalling
 

promotes cell proliferation [Pubmed]; miR-133a inhibits cervical cancer growth by targeting EGFR [Pubmed]

invasion and metastasis invasion and metastasis
 
 

upregulation of EGFR and c-Met is associated with epithelial mesenchymal transition in response to increased matrix rigidity in lung adenocarcinoma [Pubmed]; EGFR-L858R mutant enhances lung adenocarcinoma cell invasive ability and promotes malignant pleural effusion formation through activation of the CXCL12-CXCR4 pathway [Pubmed]; promotes metastasis by altering mitochondria dynamics in NSCLC [Pubmed]

change of cellular energetics change of cellular energetics
 

EGFR inhibitors reverse Warburg effect and reactivate oxidative phosphorylation of cancer cells in NSCLC [Pubmed]; stimulates mitochondrial fission and redistribution in the lamellipodia, upregulates cellular ATP production, and enhances motility in vitro and in vivo in NSCLC [Pubmed]; EGFR signalling enhances aerobic glycolysis in Triple-Negative Breast Cancer cells to promote tumour growth and immune escape [Pubmed]

escaping immune response to cancer escaping immune response to cancer
 
 

EGFR activation by exon-19 deletions and L858R mutation in NSCLC induces PD-L1 expression through p-ERK1/2/p-c-Jun, which may induce the apoptosis of T cells through the PD-L1/PD-1 axis and thus enable immune escape [Pubmed]