CRLF2

cytokine receptor-like factor 2

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function summary function summary

cytokine receptor, with IL7R forms heterodimeric TSLP receptor involved in B-cell precursor proliferation and survival via JAK/STAT pathway [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer fusion, oncogene
types of alteration in cancer types of alteration in cancer overexpression is associated with activation of the JAK-STAT pathway in cell lines and transduces primary B-cell progenitors, sustaining their proliferation in B-cell precursor ALL [Pubmed]
fusion partner fusion partner IGH in Down syndrome-associated ALL [Pubmed]; P2RY8 in B-cell precursor ALL [Pubmed]
No hallmarks No hallmarks