CIITA

class II, major histocompatibility complex, transactivator

switch view
function summary function summary

transcriptional coactivator that regulates transcription of MHC I and MHC II genes [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, fusion
types of alteration in cancer types of alteration in cancer promoter is frequently hypermethylated in cancers [Pubmed]
fusion partner fusion partner C15orf65, CD274, PDCD1LG2, RALGDS, RMI2 in B-cell lymphoma [Pubmed]
escaping immune response to cancer escaping immune response to cancer
 
 

loss of function leads to downregulation of surface HLA class II expression and overexpression of ligands of the receptor molecule programmed cell death (PD-L1 and PD-L2) and thus negatively affects the tumour cell immunogenicity and the anti-tumour immune response [Pubmed]