CHEK2

CHK2 checkpoint homolog (S. pombe)

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function summary function summary

a serine/threonine kinase, key component of the DNA damage response, upon DNA damage, CHK2 is phosphorylated by ATM or DNA-PKcs, and activates through phosphorylation proteins involved in DNA repair, cell cycle regulation, p53 signalling, and apoptosis [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
senescence senescence promotes senescence [Pubmed]
cell division control cell division control stabilises p53 upon gamma-irradiation-induced DNA damage inducing cell-cycle arrest in the G2 phase [Pubmed]
impact of mutation on function impact of mutation on function K373E mutation disrupts CHK2 autophosphorylation as well as kinase activity, thus leading to impairment of CHK2 functions in suppressing cell proliferation and promoting cell survival after ionizing radiation [Pubmed]
genome instability and mutations genome instability and mutations
 
 

activates BRCA1 after DNA damage [Pubmed]; stimulates the expression of DNA repair genes [Pubmed]; initiates DNA DSB repair through activation of BRCA2 [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

regulates transcription-independent p53-mediated apoptosis in response to DNA damage [Pubmed]; promotes anoikis in intestinal epithelial cells [Pubmed]