CBL

Cas-Br-M (murine) ecotropic retroviral transforming

switch view
function summary function summary

A RING finger E3 ubiquitin ligase, negatively regulating receptor tyrosine kinase (RTK) signalling by ubiquitination of active RTKs, targeting them for the lysosomal degradation [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, oncogene, fusion
impact of mutation on function impact of mutation on function mutations within a highly conserved alpha-helical structure linking the SH2 and RING finger domains negatively affect internalisation of EGFR and induce the transformation in fibroblasts NIH 3T3 cell line [Pubmed]
fusion partner fusion partner KMT2A [Pubmed]
proliferative signalling proliferative signalling
 

KD results in decreased proliferation and clonogenic survival in melanoma A375, G361, Hs-294T, SK-Mel-2, SK-Mel-28 and 451Lu cell line [Pubmed]

invasion and metastasis invasion and metastasis
 
 

KD results in decreased migration and invasive capacity in melanoma A375, G361, Hs-294T, SK-Mel-2, SK-Mel-28 and 451Lu cell line [Pubmed]