CASP8

caspase 8, apoptosis-related cysteine peptidase

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function summary function summary

aspartate?specific cysteine protease, essential part of a death?inducing signalling complex (DISC) [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
impact of mutation on function impact of mutation on function Q482H mutation of procaspase-8 abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization in AML [Pubmed]
angiogenesis angiogenesis
 
 

through activation of NF-kB, enhances the expression and secretion of VEGF, IL-6, IL-8, IL-1beta and MCP-1, leading to neovascularization in GBM [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

activates caspase?3 and caspase?7 by proteolytic cleavage, thus initiating apoptosis [Pubmed]

proliferative signalling proliferative signalling
 

KD strongly decreases cell growth by delaying G0/G1- to S-phase transition and increasing p21, p27 and hypo-phosphorylated/active form of pRb levels in TN breast cancer MDA-MB-231 cell line [Pubmed]

invasion and metastasis invasion and metastasis
 
 

promotes cell migration and metastasis in non-apoptotic cells [Pubmed]; KD increases migratory and metastatic capacity in TN breast cancer MDA-MB-231 cell line [Pubmed]

tumour promoting inflammation tumour promoting inflammation
 
 

both positively and negatively regulates NLRP3 inflammasome [Pubmed]; negatively regulates expression of pro-inflammatory genes and inflammatory signalling, inhibits necroptosis [Pubmed]