CALR

calreticulin

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function summary function summary

a chaperon protein that directs proper conformation of proteins and glycoproteins in the ER, and plays a role in homeostatic control of cytosolic and ER calcium levels; also involved in wound healing, the immune response, and fibrosis [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer oncogene
types of alteration in cancer types of alteration in cancer frameshift mutations in exon 9 [Pubmed]
impact of mutation on function impact of mutation on function overexpression of L367fs*46 CALR deletion caused cytokine-independent growth in vitro due to the activation of STAT5 in mouse Ba/F3 cell line [Pubmed]; loss of C-terminal domain, containing ER-retention signal results in changed subcellular localisation of mutant protein; mutant C-terminal domain binds to and inactivates CALR autoinhibitory domain increasing its ability to activate MPL (thrombopoietin receptor) [Pubmed]
angiogenesis angiogenesis
 
 

overexpression enhances angiogenesis in gastric cancer [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

increases resistance to anoikis in oesophageal SCC [Pubmed]

proliferative signalling proliferative signalling
 

KD results in significantly reduced growth rate in oral SCC [Pubmed]; activates the JAK2 downstream pathway via its association with c-MPL, promoting proliferation in IPSC-derived hematopoietic cells [Pubmed]

invasion and metastasis invasion and metastasis
 
 

high expression is associated with increased invasiveness in gastric cancer [Pubmed]; promotes cell motility in oesophageal SCC [Pubmed]; KD impairs cell motility and anchorage-independent growth in oral SCC [Pubmed]