BCOR

BCL6 corepressor

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function summary function summary

co-repressor that potentiates transcriptional repression by BCL-6 [Pubmed]; counteracts the oncogenic active NOTCH to restrain transformation in T-ALL [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG, fusion
global regulation of gene expression global regulation of gene expression the BCOR complex contains Polycomb group proteins, including a histone H2A ubiquitin E3 ligase, an SCF ubiquitin E3 ligase, and a JmjC domain histone H3 K36 demethylase, which through epigenetic modifications of chromatin, enable silencing of BCL6 targets [Pubmed]
differentiation and development differentiation and development required for vertebrate laterality determination [Pubmed]; helps control myeloid cell differentiation [Pubmed]
types of alteration in cancer types of alteration in cancer internal tandem duplications (ITDs) involving exon 15 in high-grade uterine sarcoma [Pubmed]
impact of mutation on function impact of mutation on function deletion of exon 4 results in Myc hyperactivation and induces leukaemic transformation in T-ALL [Pubmed]
fusion partner fusion partner RARA in APL [Pubmed]; ZC3H7B in endometrial stromal sarcoma [Pubmed]; CCNB3 in undifferentiated sarcomas of male children [Pubmed]; MAML3 in undifferentiated small blue round cell sarcoma [Pubmed]
suppression of growth suppression of growth
 

LOF mutations result in increased proliferation, while overexpression impairs proliferation in bone marrow cells [Pubmed]