BAP1

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

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function summary function summary

a deubiquitylase associated with multi-protein complexes that regulate the cell cycle, cellular differentiation, cell death, gluconeogenesis and the DNA damage response [Pubmed]; crucial for histone H2A deubiquitination [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer TSG
cell division control cell division control important in the G1/S transition, regulates the levels of cell cycle proteins by affecting E2F1-dependent S-phase gene expression [Pubmed]
types of alteration in cancer types of alteration in cancer altered by Copy Number Loss, mutation, and/or loss of protein expression in over 70% of tumour samples in malignant peritoneal mesothelioma [Pubmed]
genome instability and mutations genome instability and mutations
 
 

inactivation results in chromosome instability caused by lack of gamma-tubulin deubiquitination during mitosis in breast adenocarcinoma MDA-MB-468 cell line [Pubmed]

escaping programmed cell death escaping programmed cell death
 
 

suppression of deubiquitinating activity or nuclear localisation of BAP1 reduces its ability to promote apoptosis in NSCLC NCI-H226 cell line [Pubmed]; KD causes drop in the protein levels of survivin, a member of anti-apoptotic proteins and increases apoptosis in melanoma [Pubmed]; localised at ER, it regulates the release of calcium ions from the ER to cytoplasm that promotes apoptosis; reduced levels of BAP1 at ER result in resistance to apoptosis in primary fibroblasts an mesothelial cells [Pubmed]

proliferative signalling proliferative signalling
 

promotes cancer cell proliferation by deubiquitinating and stabilising KLF5 in breast cancer [Pubmed]

invasion and metastasis invasion and metastasis
 
 

KD reduces the invasiveness of cells in uveal melanoma OCM1 and OM431 cell line [Pubmed]; promotes metastasis by deubiquitinating and stabilising KLF5, KD decreases cell migration and invasiveness in vitro and inhibits lung metastasis in mouse model in breast cancer [Pubmed]

change of cellular energetics change of cellular energetics
 

overexpression decreases ubiquitination of PGC-1alpha, protecting it from degradation and promoting gluconeogenesis [Pubmed]