ATF1

activating transcription factor 1

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function summary function summary

transcription factor, activates transcription in response to cAMP-dependent protein kinase A [Pubmed]; binding of Atf1 to promoters serves as a barrier to phase nucleosome arrays and avoid cryptic transcription [Pubmed]

Suppresses Gene name Field Field Promotes
proliferative signalling suppression of growth escaping immunicresponse to cancer cell replicativeimmortality tumour promotinginflammation invasion and metastasis angiogenesis genome instabilityand mutations escaping programmedcell death change ofcellular energetics P S
This census gene has a hallmark. For more information please look [here].
role in cancer role in cancer fusion
impact of mutation on function impact of mutation on function fusion protein binds to ATF sites present in cAMP-responsive promoters via the ATF1 bZIP domain and activates transcription constitutively in a manner that is dependent on an activation domain present in EWSR1 in malignant melanoma of soft parts [Pubmed]
fusion partner fusion partner EWSR1 in malignant melanoma of soft parts [Pubmed]
No hallmarks No hallmarks